Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cca.2009.11.002
Title: C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population
Authors: Wen, J.
Guo, Y.
Liu, X.
Liang, Y.
Wang, F.
Duan, X.
Wang, N.
Sun, L.
Wong, T.Y. 
Keywords: C-reactive protein
Diabetes mellitus
Gamma-glutamyltransferase
Issue Date: 2010
Source: Wen, J., Guo, Y., Liu, X., Liang, Y., Wang, F., Duan, X., Wang, N., Sun, L., Wong, T.Y. (2010). C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population. Clinica Chimica Acta 411 (3-4) : 198-203. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cca.2009.11.002
Abstract: Background: We studied the association of C-reactive protein (CRP), gamma-glutamyltransferase (GGT) and type 2 diabetes in Chinese. Method: A population-based cross-sectional study. Results: CRP and GGT levels were significantly higher in participants with diabetes than in those without (P < 0.001). Higher CRP levels were positively associated with prevalent type 2 diabetes after adjustment for age, sex, smoking, alcohol consumption, physical activity, family history of diabetes, body mass index, waist circumference, waist/hip ratio, education, systolic blood pressure, triglycerides, high density lipoprotein cholesterol, use of antihypertensive drugs, aspirin and lipid-lowering agents, with multivariable odds ratios (OR) of 1.55 (95% confidence interval (CI), 1.05-2.27, P trend = 0.005, comparing quartile 4 to quartile 1). However, after further adjustment for GGT, the association was completely attenuated (fourth quartile OR 1.23, 95% CI, 0.83-1.82, P trend = 0.127). Moreover, the association of CRP and prevalent type 2 diabetes was stronger in subjects with GGT values above the median than in those with GGT values below the median. Increasing serum GGT quartiles were positively associated with prevalent type 2 diabetes after adjustment for potential confounding variables (P for trend < 0.001). Conclusion: CRP may not be an independent risk factor for type 2 diabetes, at least in Chinese people. Crown Copyright © 2009.
Source Title: Clinica Chimica Acta
URI: http://scholarbank.nus.edu.sg/handle/10635/26533
ISSN: 00098981
DOI: 10.1016/j.cca.2009.11.002
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

11
checked on Dec 7, 2017

WEB OF SCIENCETM
Citations

9
checked on Nov 23, 2017

Page view(s)

180
checked on Dec 11, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.