Please use this identifier to cite or link to this item:
|Title:||Separation of model mixtures of epsilon-globin positive fetal nucleated red blood cells and anucleate erythrocytes using a microfluidic device|
Silicon cross-flow filter
|Citation:||Lee, D., Xu, G., Sukumar, P., Mahyuddin, A., Choolani, M. (2010). Separation of model mixtures of epsilon-globin positive fetal nucleated red blood cells and anucleate erythrocytes using a microfluidic device. Journal of Chromatography A 1217 (11) : 1862-1866. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chroma.2010.01.065|
|Abstract:||Microfluidic devices are capable of separating microparticles and cells. We developed and tested the efficiency of silicon cross-flow microfilters for the separation of primitive fetal nucleated red blood cells (FNRBCs) and adult anucleate red blood cell (AARBCs) from model mixtures. Stepwise improvements over three generations of device design resulted in an increasing trend in the recovery of FNRBCs. We obtained a recovery of FNRBCs (74.0 ± 6.3%, p < 0.05, n = 5) using the third generation device, with a depletion of 46.5 ± 3.2% AARBCs from the cell mixture. The purity of FNRBCs in the enriched fraction was enhanced by a factor of 1.7-fold. © 2010 Elsevier B.V. All rights reserved.|
|Source Title:||Journal of Chromatography A|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 10, 2018
WEB OF SCIENCETM
checked on Nov 26, 2018
checked on Dec 9, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.