Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.chroma.2008.07.021
Title: Preparation and evaluation of calix[4]arene-capped β-cyclodextrin-bonded silica particles as chiral stationary phase for high-performance liquid chromatography
Authors: Thamarai, Chelvi S.K.
Yong, E.L. 
Gong, Y. 
Keywords: β-Cyclodextrin
Calix[4]arene
Chiral separation
Chiral stationary phase
High-performance liquid chromatography
Issue Date: 2008
Source: Thamarai, Chelvi S.K., Yong, E.L., Gong, Y. (2008). Preparation and evaluation of calix[4]arene-capped β-cyclodextrin-bonded silica particles as chiral stationary phase for high-performance liquid chromatography. Journal of Chromatography A 1203 (1) : 54-58. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chroma.2008.07.021
Abstract: Calix[4]arene-capped [3-(2-O-β-cyclodextrin)-2-hydroxypropoxy]propylsilyl-appended silica particles (C4CD-HPS), a new type of substituted β-cyclodextrin-bonded chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC), have been synthesized by treatment of bromoacetate-substituted [3-(2-O-β-cyclodextrin)-2-hydroxypropoxy]propylsilyl-appended silica particles (BACD-HPS) with calix[4]arene oxyanions in anhydrous N-methyl-2-pyrrolidone. The synthetic stationary phase is characterized by means of elemental analysis. This new type of CSP has a chiral selector with two recognition sites: calix[4]arene and β-cyclodextrin (β-CD). The chromatographic behavior of C4CD-HPS was studied with several disubstituted benzenes and some chiral drug compounds under reversed-phase conditions. The results show that C4CD-HPS has excellent selectivity for the separation of aromatic positional isomers and enantiomers of chiral compounds due to the cooperative functioning of calix[4]arenes and β-CDs. © 2008 Elsevier B.V. All rights reserved.
Source Title: Journal of Chromatography A
URI: http://scholarbank.nus.edu.sg/handle/10635/26022
ISSN: 00219673
DOI: 10.1016/j.chroma.2008.07.021
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