Please use this identifier to cite or link to this item:
|Title:||Dimeric progestins from rhizomes of Ligusticum chuanxiong|
Bioassay-guided isolation and structure elucidation
Levistolide A (3)
Tokinolide B (4)
|Source:||Lim, L.S., Shen, P., Gong, Y.H., Yong, E.L. (2006). Dimeric progestins from rhizomes of Ligusticum chuanxiong. Phytochemistry 67 (7) : 728-734. ScholarBank@NUS Repository. https://doi.org/10.1016/j.phytochem.2006.01.024|
|Abstract:||Five dimeric phthalides were isolated from rhizomes of Ligusticum chuanxiong and their structures deduced based on spectral data. All compounds and their parent extracts were assessed for progesterone-like activity using a progesterone receptor driven reporter-gene bioassay. Among all the compounds, riligustilide, displayed weak progesterone-like activity (EC50 ∼ 81 μM), whereas, (3Z′)-(3a′R,6′R,3R,6R,7R)-3,8-dihydro-6. 6′,7.3a′-diligustilide (Mr: 382, EC50 ∼ 90 nM), was found to be a potent and specific activator of the progesterone receptor. Levistolide A, although having a very similar plenary structure, was inactive indicating the importance of stereochemistry of chiral centers and flexibility of butylidene side chain for progestogenic activity. These bioactive phthalides and their parent extracts (EC50 ∼ 8 μg/ml) may have utility for treatment of conditions requiring progesterone action. © 2006 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 7, 2017
WEB OF SCIENCETM
checked on Nov 29, 2017
checked on Dec 4, 2017
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.