Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.vaccine.2009.07.098
Title: Safety and efficacy of human rotavirus vaccine during the first 2 years of life in Asian infants: Randomised, double-blind, controlled study
Authors: Phua, K.B.
Lim, F.S.
Teoh, Y.L.
Lau, Y.L.
Nelson, E.A.S.
Huang, L.M.
Quak, S.H. 
Lee, B.W.
Tang, H.
Boudville, I.
Oostvogels, L.C.
Suryakiran, P.V.
Smolenov, I.V.
Han, H.H.
Bock, H.L.
Keywords: Diarrhoea
Efficacy
Gastroenteritis
Human rotavirus vaccine
Rotavirus
Issue Date: 2009
Source: Phua, K.B., Lim, F.S., Teoh, Y.L., Lau, Y.L., Nelson, E.A.S., Huang, L.M., Quak, S.H., Lee, B.W., Tang, H., Boudville, I., Oostvogels, L.C., Suryakiran, P.V., Smolenov, I.V., Han, H.H., Bock, H.L. (2009). Safety and efficacy of human rotavirus vaccine during the first 2 years of life in Asian infants: Randomised, double-blind, controlled study. Vaccine 27 (43) : 5936-5941. ScholarBank@NUS Repository. https://doi.org/10.1016/j.vaccine.2009.07.098
Abstract: This study evaluates the safety and efficacy against severe rotavirus gastroenteritis of the oral live attenuated human rotavirus vaccine RIX4414 (Rotarix™) during the first 2 years of life in Asian infants from high-income countries. Healthy infants were enrolled to receive 2 doses of RIX4414 (N = 5359) or placebo (N = 5349). From 2 weeks post-dose 2 to 2 years of age, vaccine efficacy was 96.1% (95%CI:85.1%; 99.5%) against severe rotavirus gastroenteritis, 100% (95%CI:80.8%; 100%) against wild-type G1P[8] and 93.6% (95%CI:74.7%; 99.3%) against circulating non-G1 rotavirus types. No intussusception cases were reported within 31 days post-vaccination. RIX4414 shows a good safety profile and offers high protection during the first 2 years of life with potentially significant public health impact in this population. © 2009 Elsevier Ltd. All rights reserved.
Source Title: Vaccine
URI: http://scholarbank.nus.edu.sg/handle/10635/25701
ISSN: 0264410X
DOI: 10.1016/j.vaccine.2009.07.098
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