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Title: Do viruses subvert cholesterol homeostasis to induce host cubic membranes?
Authors: Deng, Y. 
Almsherqi, Z.A. 
Ng, M.M.L. 
Kohlwein, S.D.
Issue Date: 2010
Source: Deng, Y., Almsherqi, Z.A., Ng, M.M.L., Kohlwein, S.D. (2010). Do viruses subvert cholesterol homeostasis to induce host cubic membranes?. Trends in Cell Biology 20 (7) : 371-379. ScholarBank@NUS Repository.
Abstract: Biological membranes with cubic morphology are a hallmark of stressed or diseased cellular conditions; both protein-protein interactions and lipid alterations appear to contribute to their biogenesis, yet their specific cellular functions are unknown. The occurrence of cubic membranes strikingly correlates with viral infections; notably, virus entry, proliferation, and release are processes closely linked to cellular cholesterol metabolism, and dys-regulation of cholesterol synthesis at the level of HMG-CoA reductase also induces cubic membrane formation, in the absence of viral infection. We propose that virus-induced cubic membranes could result from viral interference of cellular cholesterol homeostasis, generating a protective membrane environment to facilitate virus assembly and proliferation. Preventing cubic membrane formation might thus disrupt the 'virus factory' and offer new avenues to combat viral infections. © 2010 Elsevier Ltd.
Source Title: Trends in Cell Biology
ISSN: 09628924
DOI: 10.1016/j.tcb.2010.04.001
Appears in Collections:Staff Publications

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