Please use this identifier to cite or link to this item:
|Title:||Do viruses subvert cholesterol homeostasis to induce host cubic membranes?|
|Authors:||Deng, Y. |
|Citation:||Deng, Y., Almsherqi, Z.A., Ng, M.M.L., Kohlwein, S.D. (2010). Do viruses subvert cholesterol homeostasis to induce host cubic membranes?. Trends in Cell Biology 20 (7) : 371-379. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tcb.2010.04.001|
|Abstract:||Biological membranes with cubic morphology are a hallmark of stressed or diseased cellular conditions; both protein-protein interactions and lipid alterations appear to contribute to their biogenesis, yet their specific cellular functions are unknown. The occurrence of cubic membranes strikingly correlates with viral infections; notably, virus entry, proliferation, and release are processes closely linked to cellular cholesterol metabolism, and dys-regulation of cholesterol synthesis at the level of HMG-CoA reductase also induces cubic membrane formation, in the absence of viral infection. We propose that virus-induced cubic membranes could result from viral interference of cellular cholesterol homeostasis, generating a protective membrane environment to facilitate virus assembly and proliferation. Preventing cubic membrane formation might thus disrupt the 'virus factory' and offer new avenues to combat viral infections. © 2010 Elsevier Ltd.|
|Source Title:||Trends in Cell Biology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 19, 2018
WEB OF SCIENCETM
checked on Apr 3, 2018
checked on Mar 12, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.