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|Title:||Do viruses subvert cholesterol homeostasis to induce host cubic membranes?|
|Authors:||Deng, Y. |
|Citation:||Deng, Y., Almsherqi, Z.A., Ng, M.M.L., Kohlwein, S.D. (2010). Do viruses subvert cholesterol homeostasis to induce host cubic membranes?. Trends in Cell Biology 20 (7) : 371-379. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tcb.2010.04.001|
|Abstract:||Biological membranes with cubic morphology are a hallmark of stressed or diseased cellular conditions; both protein-protein interactions and lipid alterations appear to contribute to their biogenesis, yet their specific cellular functions are unknown. The occurrence of cubic membranes strikingly correlates with viral infections; notably, virus entry, proliferation, and release are processes closely linked to cellular cholesterol metabolism, and dys-regulation of cholesterol synthesis at the level of HMG-CoA reductase also induces cubic membrane formation, in the absence of viral infection. We propose that virus-induced cubic membranes could result from viral interference of cellular cholesterol homeostasis, generating a protective membrane environment to facilitate virus assembly and proliferation. Preventing cubic membrane formation might thus disrupt the 'virus factory' and offer new avenues to combat viral infections. © 2010 Elsevier Ltd.|
|Source Title:||Trends in Cell Biology|
|Appears in Collections:||Staff Publications|
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