Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.febslet.2006.01.070
Title: Functional and evolutionary analyses on expressed intronless genes in the mouse genome
Authors: Sakharkar, K.R. 
Pervaiz, S. 
Sakharkar, M.K.
Culiat, C.T.
Chow, V.T.K. 
Keywords: Housekeeping
Human disease
Intronless
Mouse models
Ortholog
Single exonic genes
Issue Date: 2006
Source: Sakharkar, K.R., Pervaiz, S., Sakharkar, M.K., Culiat, C.T., Chow, V.T.K. (2006). Functional and evolutionary analyses on expressed intronless genes in the mouse genome. FEBS Letters 580 (5) : 1472-1478. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2006.01.070
Abstract: Using computational approaches we have identified 2017 expressed intronless genes in the mouse genome. Evolutionary analysis reveals that 56 intronless genes are conserved among the three domains of life - bacteria, archea and eukaryotes. These highly conserved intronless genes were found to be involved in essential housekeeping functions. About 80% of expressed mouse intronless genes have orthologs in eukaryotic genomes only, and thus are specific to eukaryotic organisms. 608 of these genes have intronless human orthologs and 302 of these orthologs have a match in OMIM database. Investigation into these mouse genes will be important in generating mouse models for understanding human diseases. © 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/25083
ISSN: 00145793
DOI: 10.1016/j.febslet.2006.01.070
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