Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2005.04.013
Title: Hypericin-mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer
Authors: Du, H.
Bay, B.-H. 
Mahendran, R. 
Olivo, M.
Keywords: CNE-2
Cytokines
Hypericin
IL-6
Interleukin-6
Nasopharyngeal cancer
NPC
PDT
Photodynamic therapy
Issue Date: 2006
Source: Du, H., Bay, B.-H., Mahendran, R., Olivo, M. (2006). Hypericin-mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer. Cancer Letters 235 (2) : 202-208. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2005.04.013
Abstract: Cytokines induce inflammatory and immune responses in tumors after photodynamic therapy (PDT). Since there are no reports of IL-6 in nasopharyngeal cancer (NPC) cells following PDT, we evaluated IL-6 expression in two different NPC tumors after hypericin mediated PDT. Interleukin-6 transcription was significantly upregulated in PDT-treated CNE-2 poorly differentiated cells but not in HK1 well differentiated cells. In vivo, IL-6 mRNA expression was elevated in PDT-treated CNE-2 tumors but not in HK1 tumors. In conclusion, the study elucidated that the cell type, degree of histological differentiation and the basal expression of the cytokine influence the cytokine response following PDT. © 2005 Elsevier Ireland Ltd. All rights reserved.
Source Title: Cancer Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/24204
ISSN: 03043835
DOI: 10.1016/j.canlet.2005.04.013
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