Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/23216
Title: Molecular profile of periodontal tissues following tooth replantation
Authors: TARUN KUMAR MAHESHWARI
Keywords: Molecular biology, Periodontal ligament, Gene expression, Wound healing, Avulsion
Issue Date: 29-Aug-2007
Source: TARUN KUMAR MAHESHWARI (2007-08-29). Molecular profile of periodontal tissues following tooth replantation. ScholarBank@NUS Repository.
Abstract: Delayed replantation of avulsed teeth results in adverse consequences of ankylosis/replacement resorption ultimately leading to tooth loss. Using high density oligonucleotide arrays, the early genetic profiles of alveolar bone and periodontal ligament (PDL), which are the two key entities in periodontal healing following tooth replantation, were determined in a canine model. The group of immediately replanted teeth likely leading to favorable healing (FH) served as control over the group of 60-minute delayed replanted teeth likely leading to unfavorable healing (UH). The expression of genes were evaluated in 3 comparisons namely temporal (timeline), conditional and topographic. The 0 hour observation served as a baseline to understand the progression of wound healing following tooth replantation in both structural entities in comparison to different time point at day 1, 3 and 7 between the two groups in the temporal comparison. The experiment was done using 3 biological replicates for each group. This study gives insight into early molecular phenomena occuring in bone and PDL following immediate as well as delayed replantation. It also enlightens the genes which were differentially regulated in UH group when compared to the FH group in both structures.The knowledge obtained through this study can facilitate the establishment of a baseline paradigm to improve replantation strategies
URI: http://scholarbank.nus.edu.sg/handle/10635/23216
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