Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/23132
Title: Chemical studies of panax notoginseng and related species and evaluation of potential antiplatelet and anticoagulant effects
Authors: LAU AIK JIANG
Keywords: Panax notoginseng, ginsenosides, notoginsenosides, quality control, platelet aggregation, blood coagulation
Issue Date: 16-Mar-2007
Source: LAU AIK JIANG (2007-03-16). Chemical studies of panax notoginseng and related species and evaluation of potential antiplatelet and anticoagulant effects. ScholarBank@NUS Repository.
Abstract: With increasing use of herbal medicines, assessment of their safety, quality and efficacy is important. Panax notoginseng is a highly-valued Chinese medicinal herb, available in two different formsa??raw and steamed. Due to their different clinical indications, using the wrong form may be undesirable. Quality control of this herb is hence paramount. The overall objectives are to develop methods for the quality control of P. notoginseng, and to study the effects of processing, namely, the chemical and biological differences between raw and steamed P. notoginseng. In this work, new analytical methods, both qualitative and quantitative, have been developed for raw and steamed P. notoginseng roots and products from different sources. Other related Panax species, P. ginseng and P. quinquefolium, were also analysed. Key marker compounds which differentiate the two forms were isolated and identified. Their haematological activities (platelet aggregation, blood coagulation, haemostasis) were also investigated in vitro and in vivo.
URI: http://scholarbank.nus.edu.sg/handle/10635/23132
Appears in Collections:Ph.D Theses (Open)

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