Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/23128
Title: Fetal microchimerism in maternal mouse blood and brain
Authors: TAN XIAO WEI
Keywords: fetal, microchimerism, mouse, maternal, brain, GFP
Issue Date: 27-Apr-2007
Source: TAN XIAO WEI (2007-04-27). Fetal microchimerism in maternal mouse blood and brain. ScholarBank@NUS Repository.
Abstract: Fetal microchimerism has been found in maternal blood and solid organs. Microchimerism is observed in both diseased and healthy women. We investigated whether EGFP+ fetal mouse cells can enter the maternal peripheral blood, cross the blood-brain barrier and differentiate in maternal mouse brain. NMDA lesions triggered greater engraftment of fetal cells in maternal brain. Dopaminergic 6-OHDA lesions were used to study whether fetal cells can have functional effects on maternal behavior. Fetal cells were also observed to engraft into maternal spinal cord. Further studies are required to determine whether such spontaneous engraftment has any physiological or pathophysiological significance. Fetomaternal microchimerism provides a novel model for the experimental investigation of the properties that allow these cells to cross both the placental and blood-brain barriers and to target injured brain. Characteristics of these cells may improve selection procedure for isolation of progenitor or stem cells for brain repair by intravenous infusion.
URI: http://scholarbank.nus.edu.sg/handle/10635/23128
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