Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/22843
Title: Design and synthesis of novel metal complex-protein conjugation agents for applications in bio-imaging
Authors: WANG TAO
Keywords: metal-protein conjugates, bio-imaging, somatostatin, intercalation
Issue Date: 18-Jun-2010
Source: WANG TAO (2010-06-18). Design and synthesis of novel metal complex-protein conjugation agents for applications in bio-imaging. ScholarBank@NUS Repository.
Abstract: Targeting particular cells or tissues for imaging e.g. proliferative cells or for transporting drug molecules plays a vital role in cancer treatment and represents an area of high scientific interest. In order to contribute to a better detection of proliferative cells, a sophisticated metal-DOTA imaging agent was designed that is able to specifically interact with disulfide bridges of proteins by intercalating into accessible disulfide bridges via two sequential Michael addition-elimination reactions. Such DOTA-protein conjugates are highly versatile since they can be labeled with 68Ga for PET or paramagnetic metals such as Gd(?) for MR imaging. In addition, a folate-metal-DOTA conjugate has been prepared as well as a novel approach that facilitates somatostatin-metal-DOTA conjugates has been designed for targeted delivery and first attempts have been undertaken to achieve this challenging goal.
URI: http://scholarbank.nus.edu.sg/handle/10635/22843
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
master_thesis_WT.pdf4.02 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

316
checked on Dec 11, 2017

Download(s)

330
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.