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https://doi.org/10.3402/pba.v4.24824
Title: | An immunohistochemical approach for monitoring effects of exercise on tumor stromal cells in old mice. | Authors: | Pettan-Brewer, Christina Goh, Jorming Ladiges, Warren C |
Keywords: | aging breast cancer exercise immunohistochemistry tumor microenvironment tumor stromal cells |
Issue Date: | 2014 | Publisher: | Informa UK Limited | Citation: | Pettan-Brewer, Christina, Goh, Jorming, Ladiges, Warren C (2014). An immunohistochemical approach for monitoring effects of exercise on tumor stromal cells in old mice.. Pathobiology of Aging & Age-related Diseases 4 (1) : 24824-24824. ScholarBank@NUS Repository. https://doi.org/10.3402/pba.v4.24824 | Abstract: | Epidemiological evidence supports a protective effect of physical activity for breast cancer in older women, but the mechanisms are not well understood. We used 18-month-old BALB/c mice injected in the mammary fat pad with syngeneic 4T1 tumor cells as a model of invasive breast cancer. During the tumor progression phase, there was a significant decrease in labeling for F4/80, a marker for mouse macrophages, and CD34, a marker for vascular endothelial cells, in primary tumors from mice that ran higher average distances compared to mice that ran lower average distances (p≤0.05). These observations suggest that immunohistochemistry can be used to monitor stromal cell populations in tumors from old mice under exercise conditions. | Source Title: | Pathobiology of Aging & Age-related Diseases | URI: | https://scholarbank.nus.edu.sg/handle/10635/219455 | ISSN: | 2001-0001 | DOI: | 10.3402/pba.v4.24824 |
Appears in Collections: | Staff Publications Elements |
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