Please use this identifier to cite or link to this item: https://doi.org/10.3402/pba.v4.24824
Title: An immunohistochemical approach for monitoring effects of exercise on tumor stromal cells in old mice.
Authors: Pettan-Brewer, Christina
Goh, Jorming 
Ladiges, Warren C
Keywords: aging
breast cancer
exercise
immunohistochemistry
tumor microenvironment
tumor stromal cells
Issue Date: 2014
Publisher: Informa UK Limited
Citation: Pettan-Brewer, Christina, Goh, Jorming, Ladiges, Warren C (2014). An immunohistochemical approach for monitoring effects of exercise on tumor stromal cells in old mice.. Pathobiology of Aging & Age-related Diseases 4 (1) : 24824-24824. ScholarBank@NUS Repository. https://doi.org/10.3402/pba.v4.24824
Abstract: Epidemiological evidence supports a protective effect of physical activity for breast cancer in older women, but the mechanisms are not well understood. We used 18-month-old BALB/c mice injected in the mammary fat pad with syngeneic 4T1 tumor cells as a model of invasive breast cancer. During the tumor progression phase, there was a significant decrease in labeling for F4/80, a marker for mouse macrophages, and CD34, a marker for vascular endothelial cells, in primary tumors from mice that ran higher average distances compared to mice that ran lower average distances (p≤0.05). These observations suggest that immunohistochemistry can be used to monitor stromal cell populations in tumors from old mice under exercise conditions.
Source Title: Pathobiology of Aging & Age-related Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/219455
ISSN: 2001-0001
DOI: 10.3402/pba.v4.24824
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