Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.bpobgyn.2016.03.006
Title: | Cellular and Animal Studies: Insights into Pathophysiology and Therapy of PCOS | Authors: | Indran, Inthrani Raja Lee, Bao Hui Yong, Eu-Leong |
Keywords: | polycystic ovarian syndrome androgen steroidogenesis animal models |
Issue Date: | 1-Nov-2016 | Publisher: | ELSEVIER SCI LTD | Citation: | Indran, Inthrani Raja, Lee, Bao Hui, Yong, Eu-Leong (2016-11-01). Cellular and Animal Studies: Insights into Pathophysiology and Therapy of PCOS. BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY 37 : 12-24. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bpobgyn.2016.03.006 | Abstract: | Basic science studies have advanced our understanding of the role of key enzymes in the steroidogenesis pathway and those that affect the pathophysiology of PCOS. Studies with ovarian theca cells taken from women with PCOS have demonstrated increased androgen production due to increased CYP17A1 and HSD3B2 enzyme activities. Furthermore, overexpression of DENND1A variant 2 in normal theca cells resulted in a PCOS phenotype with increased androgen production. Notably, cellular steroidogenesis models have facilitated the understanding of the mechanistic effects of pharmacotherapies, including insulin sensitizers (e.g., pioglitazone and metformin) used for the treatment of insulin resistance in PCOS, on androgen production. In addition, animal models of PCOS have provided a critical platform to study the effects of therapeutic agents in a manner closer to the physiological state. Indeed, recent breakthroughs have demonstrated that natural derivatives such as the dietary medium-chain fatty acid decanoic acid (DA) can restore estrous cyclicity and lower androgen levels in an animal model of PCOS, thus laying the platform for novel therapeutic developments in PCOS. This chapter reviews the current understanding on the pathways modulating androgen biosynthesis, and the cellular and animal models that form the basis for preclinical research in PCOS, and sets the stage for clinical research. | Source Title: | BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY | URI: | https://scholarbank.nus.edu.sg/handle/10635/206076 | ISSN: | 15216934 | DOI: | 10.1016/j.bpobgyn.2016.03.006 |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
Cellular animal insights PCOS Bets Pract RCOG 2016.pdf | Published version | 846.02 kB | Adobe PDF | CLOSED | Published |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.