Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bpobgyn.2016.03.006
Title: Cellular and Animal Studies: Insights into Pathophysiology and Therapy of PCOS
Authors: Indran, Inthrani Raja 
Lee, Bao Hui
Yong, Eu-Leong 
Keywords: polycystic ovarian syndrome
androgen
steroidogenesis
animal models
Issue Date: 1-Nov-2016
Publisher: ELSEVIER SCI LTD
Citation: Indran, Inthrani Raja, Lee, Bao Hui, Yong, Eu-Leong (2016-11-01). Cellular and Animal Studies: Insights into Pathophysiology and Therapy of PCOS. BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY 37 : 12-24. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bpobgyn.2016.03.006
Abstract: Basic science studies have advanced our understanding of the role of key enzymes in the steroidogenesis pathway and those that affect the pathophysiology of PCOS. Studies with ovarian theca cells taken from women with PCOS have demonstrated increased androgen production due to increased CYP17A1 and HSD3B2 enzyme activities. Furthermore, overexpression of DENND1A variant 2 in normal theca cells resulted in a PCOS phenotype with increased androgen production. Notably, cellular steroidogenesis models have facilitated the understanding of the mechanistic effects of pharmacotherapies, including insulin sensitizers (e.g., pioglitazone and metformin) used for the treatment of insulin resistance in PCOS, on androgen production. In addition, animal models of PCOS have provided a critical platform to study the effects of therapeutic agents in a manner closer to the physiological state. Indeed, recent breakthroughs have demonstrated that natural derivatives such as the dietary medium-chain fatty acid decanoic acid (DA) can restore estrous cyclicity and lower androgen levels in an animal model of PCOS, thus laying the platform for novel therapeutic developments in PCOS. This chapter reviews the current understanding on the pathways modulating androgen biosynthesis, and the cellular and animal models that form the basis for preclinical research in PCOS, and sets the stage for clinical research.
Source Title: BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/206076
ISSN: 15216934
DOI: 10.1016/j.bpobgyn.2016.03.006
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Cellular animal insights PCOS Bets Pract RCOG 2016.pdfPublished version846.02 kBAdobe PDF

CLOSED

Published

SCOPUSTM   
Citations

7
checked on May 22, 2022

Page view(s)

52
checked on May 12, 2022

Download(s)

1
checked on May 12, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.