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https://doi.org/10.1016/j.isci.2021.102305
Title: | Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery | Authors: | Maruyama, Kazuaki Naemura, Kazuaki Arima, Yuichiro Uchijima, Yasunobu Nagao, Hiroaki Yoshihara, Kenji Singh, Manvendra K Uemura, Akiyoshi Matsuzaki, Fumio Yoshida, Yutaka Kurihara, Yukiko Miyagawa-Tomita, Sachiko Kurihara, Hiroki |
Keywords: | Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics ENDOTHELIAL-CELLS SEMAPHORIN 3E ANGIOGENESIS ORIGIN HEART FORM LYMPHANGIOGENESIS NEUROPILIN-1 CONTRIBUTES ANOMALIES |
Issue Date: | 23-Apr-2021 | Publisher: | CELL PRESS | Citation: | Maruyama, Kazuaki, Naemura, Kazuaki, Arima, Yuichiro, Uchijima, Yasunobu, Nagao, Hiroaki, Yoshihara, Kenji, Singh, Manvendra K, Uemura, Akiyoshi, Matsuzaki, Fumio, Yoshida, Yutaka, Kurihara, Yukiko, Miyagawa-Tomita, Sachiko, Kurihara, Hiroki (2021-04-23). Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery. ISCIENCE 24 (4). ScholarBank@NUS Repository. https://doi.org/10.1016/j.isci.2021.102305 | Abstract: | Blood and lymphatic vessels surrounding the heart develop through orchestrated processes from cells of different origins. In particular, cells around the outflow tract which constitute a primordial transient vasculature, referred to as aortic subepicardial vessels, are crucial for the establishment of coronary artery stems and cardiac lymphatic vessels. Here, we revealed that the epicardium and pericardium-derived Semaphorin 3E (Sema3E) and its receptor, PlexinD1, play a role in the development of the coronary stem, as well as cardiac lymphatic vessels. In vitro analyses demonstrated that Sema3E may demarcate areas to repel PlexinD1-expressing lymphatic endothelial cells, resulting in proper coronary and lymphatic vessel formation. Furthermore, inactivation of Sema3E-PlexinD1 signaling improved the recovery of cardiac function by increasing reactive lymphangiogenesis in an adult mouse model of myocardial infarction. These findings may lead to therapeutic strategies that target Sema3E-PlexinD1 signaling in coronary artery diseases. | Source Title: | ISCIENCE | URI: | https://scholarbank.nus.edu.sg/handle/10635/201069 | ISSN: | 25890042 25890042 |
DOI: | 10.1016/j.isci.2021.102305 |
Appears in Collections: | Staff Publications Elements |
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2021. Maruyama et al. iScience.pdf | Published version | 34.26 MB | Adobe PDF | OPEN | None | View/Download |
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