Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.isci.2021.102305
DC Field | Value | |
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dc.title | Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery | |
dc.contributor.author | Maruyama, Kazuaki | |
dc.contributor.author | Naemura, Kazuaki | |
dc.contributor.author | Arima, Yuichiro | |
dc.contributor.author | Uchijima, Yasunobu | |
dc.contributor.author | Nagao, Hiroaki | |
dc.contributor.author | Yoshihara, Kenji | |
dc.contributor.author | Singh, Manvendra K | |
dc.contributor.author | Uemura, Akiyoshi | |
dc.contributor.author | Matsuzaki, Fumio | |
dc.contributor.author | Yoshida, Yutaka | |
dc.contributor.author | Kurihara, Yukiko | |
dc.contributor.author | Miyagawa-Tomita, Sachiko | |
dc.contributor.author | Kurihara, Hiroki | |
dc.date.accessioned | 2021-09-27T07:18:46Z | |
dc.date.available | 2021-09-27T07:18:46Z | |
dc.date.issued | 2021-04-23 | |
dc.identifier.citation | Maruyama, Kazuaki, Naemura, Kazuaki, Arima, Yuichiro, Uchijima, Yasunobu, Nagao, Hiroaki, Yoshihara, Kenji, Singh, Manvendra K, Uemura, Akiyoshi, Matsuzaki, Fumio, Yoshida, Yutaka, Kurihara, Yukiko, Miyagawa-Tomita, Sachiko, Kurihara, Hiroki (2021-04-23). Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery. ISCIENCE 24 (4). ScholarBank@NUS Repository. https://doi.org/10.1016/j.isci.2021.102305 | |
dc.identifier.issn | 25890042 | |
dc.identifier.issn | 25890042 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/201069 | |
dc.description.abstract | Blood and lymphatic vessels surrounding the heart develop through orchestrated processes from cells of different origins. In particular, cells around the outflow tract which constitute a primordial transient vasculature, referred to as aortic subepicardial vessels, are crucial for the establishment of coronary artery stems and cardiac lymphatic vessels. Here, we revealed that the epicardium and pericardium-derived Semaphorin 3E (Sema3E) and its receptor, PlexinD1, play a role in the development of the coronary stem, as well as cardiac lymphatic vessels. In vitro analyses demonstrated that Sema3E may demarcate areas to repel PlexinD1-expressing lymphatic endothelial cells, resulting in proper coronary and lymphatic vessel formation. Furthermore, inactivation of Sema3E-PlexinD1 signaling improved the recovery of cardiac function by increasing reactive lymphangiogenesis in an adult mouse model of myocardial infarction. These findings may lead to therapeutic strategies that target Sema3E-PlexinD1 signaling in coronary artery diseases. | |
dc.language.iso | en | |
dc.publisher | CELL PRESS | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Multidisciplinary Sciences | |
dc.subject | Science & Technology - Other Topics | |
dc.subject | ENDOTHELIAL-CELLS | |
dc.subject | SEMAPHORIN 3E | |
dc.subject | ANGIOGENESIS | |
dc.subject | ORIGIN | |
dc.subject | HEART | |
dc.subject | FORM | |
dc.subject | LYMPHANGIOGENESIS | |
dc.subject | NEUROPILIN-1 | |
dc.subject | CONTRIBUTES | |
dc.subject | ANOMALIES | |
dc.type | Article | |
dc.date.updated | 2021-09-22T02:06:57Z | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1016/j.isci.2021.102305 | |
dc.description.sourcetitle | ISCIENCE | |
dc.description.volume | 24 | |
dc.description.issue | 4 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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2021. Maruyama et al. iScience.pdf | Published version | 34.26 MB | Adobe PDF | OPEN | None | View/Download |
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