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https://doi.org/10.3390/ijms18071362
| Title: | Ankyrin repeat domain 1 protein: A functionally pleiotropic protein with cardiac biomarker potential | Authors: | Ling, S.S.M Chen, Y.-T Wang, J Richards, A.M Liew, O.W |
Keywords: | alpha actinin ankyrin beta integrin biological marker calpain 3 calsequestrin caspase 3 collagenase 3 connectin cytoskeleton protein desmin early growth response factor 1 glutathione transferase growth arrest and DNA damage inducible protein 153 histone deacetylase 1 immunoglobulin enhancer binding protein mitogen activated protein kinase nucleolin plasminogen activator inhibitor 1 protein 14 3 3 protein bcl 2 protein c jun protein kinase C alpha protein p53 Rho kinase Smad3 protein talin transcription factor GATA 4 unindexed drug Y box binding protein 1 ANKRD1 protein, human ankyrin biological marker carrier protein muscle protein nuclear protein protein binding repressor protein apoptosis bioinformatics cardiomyopathy cardiovascular disease cellular distribution down regulation gene expression regulation gene overexpression gene silencing heart failure heart function heart left ventricle overload heart muscle fibrosis heart protection human hypertrophy nonhuman nuclear export signal nuclear localization signal Review signal transduction stress upregulation animal cardiac muscle cell chemistry disease predisposition genetics heart disease metabolism pathology pathophysiology protein degradation protein domain protein transport Animals Ankyrin Repeat Biomarkers Carrier Proteins Disease Susceptibility Gene Expression Regulation Heart Diseases Humans Muscle Proteins Myocytes, Cardiac Nuclear Proteins Protein Binding Protein Interaction Domains and Motifs Protein Transport Proteolysis Repressor Proteins |
Issue Date: | 2017 | Publisher: | MDPI | Citation: | Ling, S.S.M, Chen, Y.-T, Wang, J, Richards, A.M, Liew, O.W (2017). Ankyrin repeat domain 1 protein: A functionally pleiotropic protein with cardiac biomarker potential. International Journal of Molecular Sciences 18 (7). ScholarBank@NUS Repository. https://doi.org/10.3390/ijms18071362 | Rights: | Attribution 4.0 International | Abstract: | The ankyrin repeat domain 1 (ANKRD1) protein is a cardiac-specific stress-response protein that is part of the muscle ankyrin repeat protein family. ANKRD1 is functionally pleiotropic, playing pivotal roles in transcriptional regulation, sarcomere assembly and mechano-sensing in the heart. Importantly, cardiac ANKRD1 has been shown to be highly induced in various cardiomyopathies and in heart failure, although it is still unclear what impact this may have on the pathophysiology of heart failure. This review aims at highlighting the known properties, functions and regulation of ANKRD1, with focus on the underlying mechanisms that may be involved. The current views on the actions of ANKRD1 in cardiovascular disease and its utility as a candidate cardiac biomarker with diagnostic and/or prognostic potential are also discussed. More studies of ANKRD1 are warranted to obtain deeper functional insights into this molecule to allow assessment of its potential clinical applications as a diagnostic or prognostic marker and/or as a possible therapeutic target. © 2017 by the authors. | Source Title: | International Journal of Molecular Sciences | URI: | https://scholarbank.nus.edu.sg/handle/10635/183517 | ISSN: | 1661-6596 | DOI: | 10.3390/ijms18071362 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Staff Publications Elements |
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