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Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms18071362
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dc.titleAnkyrin repeat domain 1 protein: A functionally pleiotropic protein with cardiac biomarker potential
dc.contributor.authorLing, S.S.M
dc.contributor.authorChen, Y.-T
dc.contributor.authorWang, J
dc.contributor.authorRichards, A.M
dc.contributor.authorLiew, O.W
dc.date.accessioned2020-11-17T04:41:06Z
dc.date.available2020-11-17T04:41:06Z
dc.date.issued2017
dc.identifier.citationLing, S.S.M, Chen, Y.-T, Wang, J, Richards, A.M, Liew, O.W (2017). Ankyrin repeat domain 1 protein: A functionally pleiotropic protein with cardiac biomarker potential. International Journal of Molecular Sciences 18 (7). ScholarBank@NUS Repository. https://doi.org/10.3390/ijms18071362
dc.identifier.issn1661-6596
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/183517
dc.description.abstractThe ankyrin repeat domain 1 (ANKRD1) protein is a cardiac-specific stress-response protein that is part of the muscle ankyrin repeat protein family. ANKRD1 is functionally pleiotropic, playing pivotal roles in transcriptional regulation, sarcomere assembly and mechano-sensing in the heart. Importantly, cardiac ANKRD1 has been shown to be highly induced in various cardiomyopathies and in heart failure, although it is still unclear what impact this may have on the pathophysiology of heart failure. This review aims at highlighting the known properties, functions and regulation of ANKRD1, with focus on the underlying mechanisms that may be involved. The current views on the actions of ANKRD1 in cardiovascular disease and its utility as a candidate cardiac biomarker with diagnostic and/or prognostic potential are also discussed. More studies of ANKRD1 are warranted to obtain deeper functional insights into this molecule to allow assessment of its potential clinical applications as a diagnostic or prognostic marker and/or as a possible therapeutic target. © 2017 by the authors.
dc.publisherMDPI
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectalpha actinin
dc.subjectankyrin
dc.subjectbeta integrin
dc.subjectbiological marker
dc.subjectcalpain 3
dc.subjectcalsequestrin
dc.subjectcaspase 3
dc.subjectcollagenase 3
dc.subjectconnectin
dc.subjectcytoskeleton protein
dc.subjectdesmin
dc.subjectearly growth response factor 1
dc.subjectglutathione transferase
dc.subjectgrowth arrest and DNA damage inducible protein 153
dc.subjecthistone deacetylase 1
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectmitogen activated protein kinase
dc.subjectnucleolin
dc.subjectplasminogen activator inhibitor 1
dc.subjectprotein 14 3 3
dc.subjectprotein bcl 2
dc.subjectprotein c jun
dc.subjectprotein kinase C alpha
dc.subjectprotein p53
dc.subjectRho kinase
dc.subjectSmad3 protein
dc.subjecttalin
dc.subjecttranscription factor GATA 4
dc.subjectunindexed drug
dc.subjectY box binding protein 1
dc.subjectANKRD1 protein, human
dc.subjectankyrin
dc.subjectbiological marker
dc.subjectcarrier protein
dc.subjectmuscle protein
dc.subjectnuclear protein
dc.subjectprotein binding
dc.subjectrepressor protein
dc.subjectapoptosis
dc.subjectbioinformatics
dc.subjectcardiomyopathy
dc.subjectcardiovascular disease
dc.subjectcellular distribution
dc.subjectdown regulation
dc.subjectgene expression regulation
dc.subjectgene overexpression
dc.subjectgene silencing
dc.subjectheart failure
dc.subjectheart function
dc.subjectheart left ventricle overload
dc.subjectheart muscle fibrosis
dc.subjectheart protection
dc.subjecthuman
dc.subjecthypertrophy
dc.subjectnonhuman
dc.subjectnuclear export signal
dc.subjectnuclear localization signal
dc.subjectReview
dc.subjectsignal transduction
dc.subjectstress
dc.subjectupregulation
dc.subjectanimal
dc.subjectcardiac muscle cell
dc.subjectchemistry
dc.subjectdisease predisposition
dc.subjectgenetics
dc.subjectheart disease
dc.subjectmetabolism
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectprotein degradation
dc.subjectprotein domain
dc.subjectprotein transport
dc.subjectAnimals
dc.subjectAnkyrin Repeat
dc.subjectBiomarkers
dc.subjectCarrier Proteins
dc.subjectDisease Susceptibility
dc.subjectGene Expression Regulation
dc.subjectHeart Diseases
dc.subjectHumans
dc.subjectMuscle Proteins
dc.subjectMyocytes, Cardiac
dc.subjectNuclear Proteins
dc.subjectProtein Binding
dc.subjectProtein Interaction Domains and Motifs
dc.subjectProtein Transport
dc.subjectProteolysis
dc.subjectRepressor Proteins
dc.typeReview
dc.contributor.departmentMEDICINE
dc.description.doi10.3390/ijms18071362
dc.description.sourcetitleInternational Journal of Molecular Sciences
dc.description.volume18
dc.description.issue7
dc.published.statePublished
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