Please use this identifier to cite or link to this item:
https://doi.org/10.3389/fneur.2017.00161
Title: | Molecular mechanisms regulating temperature compensation of the circadian clock | Authors: | Narasimamurthy, R Virshup, D.M |
Keywords: | casein kinase I casein kinase II PER2 protein circadian rhythm DNA replication Drosophila enzyme activity enzyme regulation familial advanced sleep phase feedback system feeding behavior gene frequency hormone release mathematical model missense mutation Neurospora nonhuman oscillator protein degradation protein function protein phosphorylation protein processing Short Survey sleep parameters sleep waking cycle temperature compensation thermoregulation |
Issue Date: | 2017 | Citation: | Narasimamurthy, R, Virshup, D.M (2017). Molecular mechanisms regulating temperature compensation of the circadian clock. Frontiers in Neurology 8 (APR) : 161. ScholarBank@NUS Repository. https://doi.org/10.3389/fneur.2017.00161 | Rights: | Attribution 4.0 International | Abstract: | An approximately 24-h biological timekeeping mechanism called the circadian clock is present in virtually all light-sensitive organisms from cyanobacteria to humans. The clock system regulates our sleep-wake cycle, feeding-fasting, hormonal secretion, body temperature, and many other physiological functions. Signals from the master circadian oscillator entrain peripheral clocks using a variety of neural and hormonal signals. Even centrally controlled internal temperature fluctuations can entrain the peripheral circadian clocks. But, unlike other chemical reactions, the output of the clock system remains nearly constant with fluctuations in ambient temperature, a phenomenon known as temperature compensation. In this brief review, we focus on recent advances in our understanding of the posttranslational modifications, especially a phosphoswitch mechanism controlling the stability of PER2 and its implications for the regulation of temperature compensation. @ 2017 Narasimamurthy and Virshup. | Source Title: | Frontiers in Neurology | URI: | https://scholarbank.nus.edu.sg/handle/10635/179509 | ISSN: | 16642295 | DOI: | 10.3389/fneur.2017.00161 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_3389_fneur_2017_00161.pdf | 729.7 kB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License