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Title: Molecular mechanisms regulating temperature compensation of the circadian clock
Authors: Narasimamurthy, R 
Virshup, D.M 
Keywords: casein kinase I
casein kinase II
PER2 protein
circadian rhythm
DNA replication
enzyme activity
enzyme regulation
familial advanced sleep phase
feedback system
feeding behavior
gene frequency
hormone release
mathematical model
missense mutation
protein degradation
protein function
protein phosphorylation
protein processing
Short Survey
sleep parameters
sleep waking cycle
temperature compensation
Issue Date: 2017
Citation: Narasimamurthy, R, Virshup, D.M (2017). Molecular mechanisms regulating temperature compensation of the circadian clock. Frontiers in Neurology 8 (APR) : 161. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: An approximately 24-h biological timekeeping mechanism called the circadian clock is present in virtually all light-sensitive organisms from cyanobacteria to humans. The clock system regulates our sleep-wake cycle, feeding-fasting, hormonal secretion, body temperature, and many other physiological functions. Signals from the master circadian oscillator entrain peripheral clocks using a variety of neural and hormonal signals. Even centrally controlled internal temperature fluctuations can entrain the peripheral circadian clocks. But, unlike other chemical reactions, the output of the clock system remains nearly constant with fluctuations in ambient temperature, a phenomenon known as temperature compensation. In this brief review, we focus on recent advances in our understanding of the posttranslational modifications, especially a phosphoswitch mechanism controlling the stability of PER2 and its implications for the regulation of temperature compensation. @ 2017 Narasimamurthy and Virshup.
Source Title: Frontiers in Neurology
ISSN: 16642295
DOI: 10.3389/fneur.2017.00161
Rights: Attribution 4.0 International
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