Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/17587
Title: Studies on waprins: A novel family of snake venom proteins
Authors: DILEEP GANGADHARAN N R A
Keywords: Waprin, snake venom proteins, inland taipan (Oxyuranus microlepidotus), spitting cobra (Naja nigricollis), antimicrobial protein, omwaprin, nawaprin
Issue Date: 26-Jan-2007
Source: DILEEP GANGADHARAN N R A (2007-01-26). Studies on waprins: A novel family of snake venom proteins. ScholarBank@NUS Repository.
Abstract: Waprins belong to a new family of snake venom proteins. We studied two new members of the waprin family, a??omwaprina?? from Oxyuranus microlepidotus and a??nawaprina?? from Naja nigricollis venoms. Studies on these novel proteins may help us to develop new therapeutic tools or pharmacological agents. Since the bioavailability of waprins in the source snake venoms is low, we resorted to recombinant protein production. Omwaprin, which is cationic at physiological conditions showed dose-dependant antibacterial activity against gram-positive bacteria in radial diffusion assays. Our studies showed that this antibacterial activity is structure-dependant, salt tolerant and specifically targets bacterial membranes. The potential of this novel antibacterial protein as a research tool and as a prototype for the development of therapeutic agents will be highlighted.
URI: http://scholarbank.nus.edu.sg/handle/10635/17587
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