Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16908
Title: Parameter estimation of oscillatory systems (with application to circadian rhythms)
Authors: ANG KOK SIONG
Keywords: Parameter estimation, oscillator, identifiability analysis
Issue Date: 24-Jul-2009
Source: ANG KOK SIONG (2009-07-24). Parameter estimation of oscillatory systems (with application to circadian rhythms). ScholarBank@NUS Repository.
Abstract: Oscillatory behavior is an important and integral in cellular and physiological functions, with examples from cell cycle to circadian rhythms and others. With the explosion of biological data, there has been a shift toward systems oriented approach in biology through the creation of mathematical models and the application of mathematical analysis. These models are reverse engineered from experimental data through model identification and parameter estimation procedure, borrowing many concepts and tools from engineering field. Though the literature on model identification is already mature, the identification of oscillatory systems however is not yet routine, due to the relatively low importance of oscillations in engineering systems. This thesis aims to fill this gap by establishing a parameter estimation framework for oscillatory systems that facilitates data reconciliation between model prediction and experiments. The proposed methodology was tested on model identification of <em>Drosophila</em> circadian gene regulatory network.
URI: http://scholarbank.nus.edu.sg/handle/10635/16908
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
AngKS.pdf2.9 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

348
checked on Dec 11, 2017

Download(s)

282
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.