Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16687
Title: Studies of the effects of Vitamin E on mitochondrial Uncoupling Proteins
Authors: CHEONG YUH MENG, CLEMENT
Keywords: Uncoupling proteins, Vitamin E, ROS
Issue Date: 25-Dec-2008
Source: CHEONG YUH MENG, CLEMENT (2008-12-25). Studies of the effects of Vitamin E on mitochondrial Uncoupling Proteins. ScholarBank@NUS Repository.
Abstract: Antioxidant defences can be broadly divided into two classes; the first class is Free radical scavenger. One example is Vitamin E VE) which can ameliorate the effect of oxidative stress on cells through well known scavenging mechanisms. The other class is prophylactic antioxidants and they prevent free radical formation. One example is mitochondrial Uncoupling Proteins (UCPs) as they are thought to be able to dampen mitochondrial generation of superoxide. In this project, we discover that VE is able to activate mitochondrial UCPs. Moreover, we also find that VE may be able to up-regulate expression of cellular UCPs. Mitochondrial uncoupling through UCPs reduces ROS production. While the reduced form of VE neutralizes ROS, its oxidized form may activate UCPs, thus hinting of a new pathway in which VE prevents ROS production. This suggests that the two major classes of antioxidants could be more closely linked than previously thought.
URI: http://scholarbank.nus.edu.sg/handle/10635/16687
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
CheongYMC_01Thesis_Title_Page.pdf9.94 kBAdobe PDF

OPEN

NoneView/Download
CheongYMC_02Thesis_Pre_Main_Body.pdf14.61 kBAdobe PDF

OPEN

NoneView/Download
CheongYMC_03Thesis_Main_Body.pdf371.17 kBAdobe PDF

OPEN

NoneView/Download

Page view(s)

224
checked on Dec 11, 2017

Download(s)

412
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.