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https://doi.org/10.1371/journal.pone.0177834
| Title: | Site-specific phosphorylation of casein kinase 1δ(CK1δ) regulates its activity towards the circadian regulator PER2 | Authors: | Eng G.W.L. Edison Virshup D.M. |
Keywords: | casein kinase Idelta cycline dinaciclib PER2 protein proline staurosporine casein kinase Idelta circadian rhythm signaling protein PER2 protein, human serine threonine animal cell Article cell cycle circadian rhythm controlled study embryo enzyme activity enzyme regulation extracellular space intracellular signaling luciferase assay mouse nonhuman protein degradation protein domain protein phosphorylation protein stability signal transduction binding site chemistry gene expression regulation genetics HEK293 cell line human metabolism mutation phosphorylation Binding Sites Casein Kinase Idelta Cell Cycle Gene Expression Regulation HEK293 Cells Humans Mutation Period Circadian Proteins Phosphorylation Protein Stability Serine Signal Transduction Threonine |
Issue Date: | 2017 | Publisher: | Public Library of Science | Citation: | Eng G.W.L., Edison, Virshup D.M. (2017). Site-specific phosphorylation of casein kinase 1δ(CK1δ) regulates its activity towards the circadian regulator PER2. PLoS ONE 12 (5) : e0177834. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0177834 | Abstract: | Circadian rhythms are intrinsic ?24 hour cycles that regulate diverse aspects of physiology, and in turn are regulated by interactions with the external environment. Casein kinase 1 delta (CK1?, CSNK1D) is a key regulator of the clock, phosphorylating both stabilizing and destabilizing sites on the PER2 protein, in a mechanism known as the phosphoswitch. CK1? can itself be regulated by phosphorylation on its regulatory domain, but the specific sites involved, and the role this plays in control of circadian rhythms as well as other CK1-dependent processes is not well understood. Using a sensitized PER2 | Source Title: | PLoS ONE | URI: | https://scholarbank.nus.edu.sg/handle/10635/165794 | ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0177834 |
| Appears in Collections: | Staff Publications Elements |
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