Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16138
Title: The mechanism of chronic demyelination in PLP transgenic mice - An animal model of multiple sclerosis
Authors: LI WENJI
Keywords: Plp MS demyelination remyelination oligodendrocyte apoptosis
Issue Date: 8-May-2007
Source: LI WENJI (2007-05-08). The mechanism of chronic demyelination in PLP transgenic mice - An animal model of multiple sclerosis. ScholarBank@NUS Repository.
Abstract: AbstractPlp-tg mice are hemizygous mice (Plptg/-) which have two additional copies of the Plp gene and express about 30 % more Plp transcripts than wild-type (WT) mice. The mechanisms of long-term demyelination and the impairment of remyelination of Plp-tg mice are not known yet. Ita??s an indispendable model for the late stage of MS.The present study investigated the mechanism of demyelination and the impairment of remyelination in the Plp-tg mouse. We found that the higher ratio of immature to mature OLs in Plp-tg mice is probably due to the failure of terminal differentiation of oligodendrocytes and to the high rate of apoptosis in mature oligodendrocytes. We suggest that cytokines produced by CD4+ T cells, and microglia may also inhibit oligodendrocyte terminal differentiation, although further experiments need to be carried out to investigate this hypothesis.
URI: http://scholarbank.nus.edu.sg/handle/10635/16138
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
paper.pdf1.83 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

216
checked on Dec 11, 2017

Download(s)

157
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.