Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16009
Title: Quantification of spheroid formation mechanism by size and shape analysis
Authors: CHUA SIANG MENG
Keywords: spheroid,size distribution,shape analysis,formation,mix gaussian,roundness
Issue Date: 6-Sep-2008
Source: CHUA SIANG MENG (2008-09-06). Quantification of spheroid formation mechanism by size and shape analysis. ScholarBank@NUS Repository.
Abstract: This work aims to describe spheroid formation and growth by examining quantitatively the size distribution and shape of spheroids produced by extrusion-spheronization and rotary processing. Using image analysis, spheroid size was curve fitted to statistical distributions. Spheroid roundness was quantified using aspect ratio, eR, projected sphericity and circularity. These roundness descriptors were correlated with one another and analysed in comparison with simulated spheroid-like shapes. Results showed that spheroid size distribution followed a mixed Gaussian distribution. Image analysis revealed that during early stages of spheronization, spheroids had characteristics of bimodal size distribution and the absence of dumbbell intermediates. When roundness descriptors were correlated with individual spheroids, it could distinguish differences in spheroid shape within a population and during spheronization. Consequently, with spheroids following a mixed Gaussian distribution and the detection of spheroid shape changes, heterogeneity within the spheroid population was revealed and spheroid formation and growth could be quantified more critically.
URI: http://scholarbank.nus.edu.sg/handle/10635/16009
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
chua siang meng thesis_1.pdf3.59 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

369
checked on Jan 14, 2018

Download(s)

465
checked on Jan 14, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.