Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15676
Title: Evaluation of the impact of polymorphisms on candidate genes of allergic rhinitis and asthma on disease outcomes in the Singapore population
Authors: LIANG XIAOHUI
Keywords: Atopic diseases, candidate gene, polymorphisms, association study, functional study, Singapore population
Issue Date: 15-Dec-2006
Source: LIANG XIAOHUI (2006-12-15). Evaluation of the impact of polymorphisms on candidate genes of allergic rhinitis and asthma on disease outcomes in the Singapore population. ScholarBank@NUS Repository.
Abstract: This study aimed to investigate the association between the candidate gene polymorphisms and atopic phenotypes in Singapore population. The following polymorphisms of candidate genes, including CD14 (-159, -550, -1145, and -1359), IL-4 (-590), IL-18 (-137, +113 and +127), I?2-adrenergic receptor (B2AR) (Arg16Gly and Gln27Glu) and Toll-like receptor 4 (TLR-4) (Asp299Gly and Thr399Ile) were genotyped using direct PCR-sequencing or RFLP methods in Singaporean Chinese (n=331), Malays (n=51) and Asian Indians (n=101). Furthermore, the polymorphisms of CD14 promoter and IL-18 5a?? non-trancription region were investigated by reporter assay in different cell-lines (THP-1, U937, HepG2 and HeLa). The results of this study are not completely consistent with some literature reports in other ethnic populations. However, it confirms that predisposition to atopy is influenced by complex immune processes, including interaction of multiple genes, interaction of environmental and genetic factors, and population heterogeneity.
URI: http://scholarbank.nus.edu.sg/handle/10635/15676
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
submission(Liang Xiaohui).pdf4.67 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

227
checked on Dec 11, 2017

Download(s)

412
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.