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https://doi.org/10.1002/smll.201602293
Title: | A Porphyrin-Based Conjugated Polymer for Highly Efficient In Vitro and In Vivo Photothermal Therapy | Authors: | GUO, BING FENG, GUANGXUE MANGHNANI, PURNIMA NARESH CAI, XIAOLEI LIU, JIE WU, WENBO XU, SHIDANG CHENG, XIAMIN TEH, CATHLEEN LIU, BIN |
Keywords: | Science & Technology Physical Sciences Technology Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics INDUCED EMISSION CHARACTERISTICS CORE-SHELL NANOPARTICLES CANCER-CELLS CONVERSION EFFICIENCY ORGANIC NANOPARTICLES SELF-AGGREGATION OXIDATIVE STRESS POLYANILINE NANOPARTICLES PHOTODYNAMIC THERAPY GOLD NANOPARTICLES |
Issue Date: | 7-Dec-2016 | Publisher: | WILEY-V C H VERLAG GMBH | Citation: | GUO, BING, FENG, GUANGXUE, MANGHNANI, PURNIMA NARESH, CAI, XIAOLEI, LIU, JIE, WU, WENBO, XU, SHIDANG, CHENG, XIAMIN, TEH, CATHLEEN, LIU, BIN (2016-12-07). A Porphyrin-Based Conjugated Polymer for Highly Efficient In Vitro and In Vivo Photothermal Therapy. SMALL 12 (45) : 6243-6254. ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201602293 | Abstract: | © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Conjugated polymers have been increasingly studied for photothermal therapy (PTT) because of their merits including large absorption coefficient, facile tuning of exciton energy dissipation through nonradiative decay, and good therapeutic efficacy. The high photothermal conversion efficiency (PCE) is the key to realize efficient PTT. Herein, a donor–acceptor (D–A) structured porphyrin-containing conjugated polymer (PorCP) is reported for efficient PTT in vitro and in vivo. The D–A structure introduces intramolecular charge transfer along the backbone, resulting in redshifted Q band, broadened absorption, and increased extinction coefficient as compared to the state-of-art porphyrin-based photothermal reagent. Through nanoencapsulation, the dense packing of a large number of PorCP molecules in a single nanoparticle (NP) leads to favorable nonradiative decay, good photostability, and high extinction coefficient of 4.23 × 104m−1 cm−1 at 800 nm based on porphyrin molar concentration and the highest PCE of 63.8% among conjugated polymer NPs. With the aid of coloaded fluorescent conjugated polymer, the cellular uptake and distribution of the PorCP in vitro can be clearly visualized, which also shows effective photothermal tumor ablation in vitro and in vivo. This research indicates a new design route of conjugated polymer-based photothermal therapeutic materials for potential personalized theranostic nanomedicine. | Source Title: | SMALL | URI: | https://scholarbank.nus.edu.sg/handle/10635/155309 | ISSN: | 16136810 16136829 |
DOI: | 10.1002/smll.201602293 |
Appears in Collections: | Staff Publications Elements |
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