Please use this identifier to cite or link to this item: https://doi.org/10.1002/smll.201602293
Title: A Porphyrin-Based Conjugated Polymer for Highly Efficient In Vitro and In Vivo Photothermal Therapy
Authors: GUO, BING 
FENG, GUANGXUE 
MANGHNANI, PURNIMA NARESH
CAI, XIAOLEI 
LIU, JIE 
WU, WENBO 
XU, SHIDANG 
CHENG, XIAMIN 
TEH, CATHLEEN 
LIU, BIN 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
INDUCED EMISSION CHARACTERISTICS
CORE-SHELL NANOPARTICLES
CANCER-CELLS
CONVERSION EFFICIENCY
ORGANIC NANOPARTICLES
SELF-AGGREGATION
OXIDATIVE STRESS
POLYANILINE NANOPARTICLES
PHOTODYNAMIC THERAPY
GOLD NANOPARTICLES
Issue Date: 7-Dec-2016
Publisher: WILEY-V C H VERLAG GMBH
Citation: GUO, BING, FENG, GUANGXUE, MANGHNANI, PURNIMA NARESH, CAI, XIAOLEI, LIU, JIE, WU, WENBO, XU, SHIDANG, CHENG, XIAMIN, TEH, CATHLEEN, LIU, BIN (2016-12-07). A Porphyrin-Based Conjugated Polymer for Highly Efficient In Vitro and In Vivo Photothermal Therapy. SMALL 12 (45) : 6243-6254. ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201602293
Abstract: © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Conjugated polymers have been increasingly studied for photothermal therapy (PTT) because of their merits including large absorption coefficient, facile tuning of exciton energy dissipation through nonradiative decay, and good therapeutic efficacy. The high photothermal conversion efficiency (PCE) is the key to realize efficient PTT. Herein, a donor–acceptor (D–A) structured porphyrin-containing conjugated polymer (PorCP) is reported for efficient PTT in vitro and in vivo. The D–A structure introduces intramolecular charge transfer along the backbone, resulting in redshifted Q band, broadened absorption, and increased extinction coefficient as compared to the state-of-art porphyrin-based photothermal reagent. Through nanoencapsulation, the dense packing of a large number of PorCP molecules in a single nanoparticle (NP) leads to favorable nonradiative decay, good photostability, and high extinction coefficient of 4.23 × 104m−1 cm−1 at 800 nm based on porphyrin molar concentration and the highest PCE of 63.8% among conjugated polymer NPs. With the aid of coloaded fluorescent conjugated polymer, the cellular uptake and distribution of the PorCP in vitro can be clearly visualized, which also shows effective photothermal tumor ablation in vitro and in vivo. This research indicates a new design route of conjugated polymer-based photothermal therapeutic materials for potential personalized theranostic nanomedicine.
Source Title: SMALL
URI: https://scholarbank.nus.edu.sg/handle/10635/155309
ISSN: 16136810
16136829
DOI: 10.1002/smll.201602293
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