Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15437
Title: The chemopreventive property of parthenolide, A Sesquiterpene lactone
Authors: WON YEN KIM
Keywords: ultraviolet (UV)-B, JB6, PKC, JNK, p38, AP-1
Issue Date: 29-May-2006
Source: WON YEN KIM (2006-05-29). The chemopreventive property of parthenolide, A Sesquiterpene lactone. ScholarBank@NUS Repository.
Abstract: Parthenolide (PN) is the principal sesquiterpene lactone of feverfew (Tanacetum parthanium) with known anti-inflammatory activity. The main objective of this study is to systematically evaluate the anti-cancer property of parthenolide using a combination of in vivo and in vitro approaches. We first tested the anti-cancer effect of PN in UVB-induced skin cancer model. SKH-1 hairless mice fed with PN (1 mg/day) showed a delayed onset of papilloma incidence, a significant reduction in papilloma multiplicity (papilloma/mouse) and sizes when compared to the UVB-only group. We next investigated the molecular mechanism(s) involved in its anti-cancer effects using cultured JB6 murine epidermal cells. Non-cytotoxic concentrations of PN selectively promote PKCI' but suppress PKCI?. In addition, PN pretreatment also inhibited c-Jun-N-terminal kinase (JNK) and p38 kinase activation, leading to suppression of the pro-survival AP-1 transcription factor. More importantly, we found that selective regulation of PKC, impaired AP-1, JNK and p38 signaling lead to the sensitization of JB6 cells to UVB-induced apoptosis.
URI: http://scholarbank.nus.edu.sg/handle/10635/15437
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
WonYenKim-Thesis.pdf2.3 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

247
checked on Dec 11, 2017

Download(s)

321
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.