Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15368
Title: The role of the ataxia - telangiectasia mutated protein in bone development
Authors: NASLIN RASHEED
Keywords: ATM, Ataxia – Telangiectasia, Bone, Osteoporosis, Hypogonadism, Estrogen
Issue Date: 18-Jun-2006
Source: NASLIN RASHEED (2006-06-18). The role of the ataxia - telangiectasia mutated protein in bone development. ScholarBank@NUS Repository.
Abstract: ATM stands for Ataxia Telangiectasia Mutated. Mutations of this gene in humans results in the rare genetic disorder, Ataxia -Telangiectasia. ATM functions as a DNA damage sensor and a checkpoint control protein. In response to DNA damage, ATM and other checkpoint proteins such as c-Abl and p53 initiate a complex signal transduction cascade to halt the cell cycle and facilitate repair. A-T patients are predisposed to developing cancer due to non-functional ATM, and also show premature aging, sterility, diabetes, and growth defects. Most of these features are recapitulated in the Atm-/- mice. Knockout mice of Atm downstream targets p53 and c-Abl both exhibit aberrant bone development. In vivo and in vitro studies of Atm-/- mice indicate accelerated bone resorption, compromised bone formation and hypogonadism. This is the first link between Atm deficiency and steroid hormone shortage. The female Atm-/- mouse could be a potential animal model for post a?? menopausal osteoporosis.
URI: http://scholarbank.nus.edu.sg/handle/10635/15368
Appears in Collections:Master's Theses (Open)

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Table of contents.pdf125.95 kBAdobe PDF

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Title page.pdf12.78 kBAdobe PDF

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Bibliography.pdf133.36 kBAdobe PDF

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Chapter 1- Introduction.pdf291.56 kBAdobe PDF

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Chapter 2 - Materials and Methods.pdf107.34 kBAdobe PDF

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Chapter 3 - Results.pdf397.47 kBAdobe PDF

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Chapter 4 - Discussion.pdf137.97 kBAdobe PDF

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