Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/14732
Title: Role of allergy and mucosal inflammation in nasal polyps and chronic sinusitis
Authors: HAO JING
Keywords: nasal polyps, chronic sinusitis, eosinophil, CD8+ T cell, natural killer cell, Trichophyton rubrum
Issue Date: 16-Jun-2005
Source: HAO JING (2005-06-16). Role of allergy and mucosal inflammation in nasal polyps and chronic sinusitis. ScholarBank@NUS Repository.
Abstract: Nasal polyps and chronic sinusitis are closely related diseases with unclear pathogenesis. Our study is aimed to investigate the association of allergy and the pattern of mucosal inflammation in Asian patients with these diseases. Inflammatory cell pattern characterized by significantly higher CD8+ T cell, eosinophil and neutrophil scores, and an inverse median ratio of CD4+/CD8+ T cells in nasal polyps/inflamed sinus mucosa and adjacent middle turbinates was demonstrated by immunohistochemical staining with a panel of antibodies. A significantly increased NK cell number was evidenced in nasal polyp tissue. Immunoarray dotblot with 185 allergens revealed that Trichophyton rubrum was the most important allergen in the patients. This was proved by western blot. By Q-TOFa??-MS/MS, HPLC and N-terminal sequencing, proteins from Trichophyton rubrum which are homologous with a 35 kD heat shock protein (sti35) and 1, 3-I?-glucanosyltransferase of Fusarium spp. were proved to have the strongest antigenecity in these patients.
URI: http://scholarbank.nus.edu.sg/handle/10635/14732
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
01 Chapter.pdf1.36 MBAdobe PDF

OPEN

NoneView/Download
02 Chapter.pdf1.89 MBAdobe PDF

OPEN

NoneView/Download
03chapter.pdf1.97 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

523
checked on Jan 19, 2018

Download(s)

1,168
checked on Jan 19, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.