Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/14707
Title: | Characterization of CMX-13 and evaluation of efficacy and mechanisms of action in animal model of autoimmunity | Authors: | RAMGOLAM VINOD SATISCH | Keywords: | Apoptosis, Allograft rejection, Immunosuppressant, Systemic Lupus Erythematosus, Chinese Medicine | Issue Date: | 22-Mar-2005 | Citation: | RAMGOLAM VINOD SATISCH (2005-03-22). Characterization of CMX-13 and evaluation of efficacy and mechanisms of action in animal model of autoimmunity. ScholarBank@NUS Repository. | Abstract: | T-cells, which are inhibited in their apoptotic mechanism, induce Systemic Lupus Erythematosus (SLE). In our previous studies we have shown that CMX-13, a derivative from a Chinese Medicine, is a potent immunosuppressant. Here we have made an effort to elucidate the structure of the bioactive compound in CMX-13, the immunosuppressive mechanism in-vitro and in-vivo, and the effect of mRNA expression levels of cytokines in-vivo. Structure elucidation experiments suggest that CMX-13 is a hexapeptide. CMX-13 was able to accelerate apoptosis in Jurkat cells and PBMCs derived from SLE patients; improved pathogical factors significantly of the MRL-lpr/lpr mice SLE mouse model. However, no effect on the cytokine expression levels in moribund mice was observed. From these experiments we concluded that CMX-13 acts as an immunosuppressant by the induction of apoptosis on T-cells. We recommend further study on the effect of CMX-13 on the molecular mechanism of apoptosis. | URI: | http://scholarbank.nus.edu.sg/handle/10635/14707 |
Appears in Collections: | Ph.D Theses (Open) |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
Thesis.pdf | 3.16 MB | Adobe PDF | OPEN | None | View/Download |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.