Please use this identifier to cite or link to this item: https://doi.org/10.1093/jjco/hyw153
Title: Extensive peritoneal lavage after curative gastrectomy for gastric cancer (EXPEL): Study protocol of an international multicentre randomised controlled trial
Authors: Kim G.
Chen E.
Tay A.Y.L.
Lee J.S.
Phua J.N.S.
Shabbir A. 
So J.B.Y. 
Tai B.C.
Keywords: Extensive peritoneal lavage
Gastrectomy
Gastric cancer
Protocol
Randomised control trial
Issue Date: 26-Feb-2017
Publisher: Oxford University Press
Citation: Kim G., Chen E., Tay A.Y.L., Lee J.S., Phua J.N.S., Shabbir A., So J.B.Y., Tai B.C. (2017-02-26). Extensive peritoneal lavage after curative gastrectomy for gastric cancer (EXPEL): Study protocol of an international multicentre randomised controlled trial. Japanese Journal of Clinical Oncology 47 (2) : 179-184. ScholarBank@NUS Repository. https://doi.org/10.1093/jjco/hyw153
Abstract: Peritoneal recurrence after gastrectomy for gastric cancer is common and the prognosis is dismal. Recent evidence suggests that extensive peritoneal lavage with large volume of normal saline after surgery before abdominal closure can reduce the risk of peritoneal recurrence and improve overall survival. This study aims to evaluate the benefit of extensive intraoperative peritoneal lavage. This is a prospective, open-label, multicentre randomised controlled trial involving 15 international centres in China, Korea, Japan, Malaysia and Singapore. Patients with cT3/4 stomach cancer undergoing curative resection are randomised to either extensive peritoneal lavage (10 l of saline) or standard lavage (?2 l of saline). The primary outcome is overall survival and secondary outcomes include disease-free survival and peritoneal recurrence. The minimum sample size is 600 subjects with 300 per arm completing 3 years follow-up. The data will be analysed on an intention-to-treat basis, assuming a two-sided test with a 5% level of significance. � The Author 2016. Published by Oxford University Press. All rights reserved.
Source Title: Japanese Journal of Clinical Oncology
URI: http://scholarbank.nus.edu.sg/handle/10635/146721
ISSN: 03682811
DOI: 10.1093/jjco/hyw153
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