Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/143286
Title: UNDERSTANDING THE ROLE OF TREHALOSE IN REGULATING MYCOLIC ACID BIOSYNTHESIS IN MYCOBACTERIA
Authors: LIM DAO TIAN JUSTIN
Keywords: Trehalose; Mycolic Acid; Mycobacteria
Issue Date: 15-Jun-2015
Citation: LIM DAO TIAN JUSTIN (2015-06-15). UNDERSTANDING THE ROLE OF TREHALOSE IN REGULATING MYCOLIC ACID BIOSYNTHESIS IN MYCOBACTERIA. ScholarBank@NUS Repository.
Abstract: TREHALOSE PLAYS AN IMPORTANT ROLE IN MYCOBACTERIA, PERFORMING VARIOUS FUNCTIONS SUCH AS BEING THE CARRIAGE OF MYCOLIC ACIDS AND IN THE FUNCTIONALIZATION OF MYCOLIC ACIDS INTO OM GLYCOLIPIDS. EARLIER WORK DONE BY THE AUTHOR SUGGESTED THAT NEW TYPES OF MYCOLIC ACID INTERMEDIATES ARE ACCUMULATING IN BOTH THE PRESENCE AND ABSENCE OF EXOGENOUS TREHALOSE IN A MYCOBACTERIUM SMEGMATIS STRAIN THAT IS AN AUXOTROPH FOR TREHALOSE. HOWEVER, THE IDENTITIES OF THESE INTERMEDIATES HAVE YET TO BE CHARACTERIZED.IN THIS WORK, WE AIMED TO CHARACTERIZE THESE MYCOLIC ACID INTERMEDIATES BY FIRST VERIFYING THEIR IDENTITIES AS MYCOLATES. THEREAFTER, WE TRIED TO CHARACTERIZE THEIR INTERMEDIATES FURTHER TO ELUCIDATE THEIR IDENTITIES. HOWEVER, WE WERE UNSUCCESSFUL IN OUR ATTEMPTS. FURTHER OPTIMIZATION OF THE EXPERIMENTS PERFORMED HAS BEEN PLANNED. DATA FROM THESE CHARACTERIZATIONS STUDIES THAT WILL BETTER OUR UNDERSTANDING OF HOW TREHALOSE COULD REGULATE MYCOLIC ACID BIOSYNTHESIS.
URI: http://scholarbank.nus.edu.sg/handle/10635/143286
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
LimDTJ.pdf1.56 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

12
checked on Sep 13, 2018

Download(s)

9
checked on Sep 13, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.