Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/14066
Title: Immunoregulatory abnormalities in childhood idiopathic nephrotic syndrome
Authors: CHEUNG WAI, WILSON
Keywords: minimal change nephrotic syndrome (MCNS), immunoregulatory abnormality, human leukocyte antigen (HLA), cytokine, interleukin (IL)-13, NF-kB
Issue Date: 2-Jun-2004
Source: CHEUNG WAI, WILSON (2004-06-02). Immunoregulatory abnormalities in childhood idiopathic nephrotic syndrome. ScholarBank@NUS Repository.
Abstract: In genetically predisposed individuals, dysregulated expression of cytokine(s) may be responsible for the minimal change nephrotic syndrome (MCNS) in childhood. This thesis confirmed the presence of a strong genetic susceptibility in Singapore Chinese children. Interleukin (IL)-13 may be implicated in the pathogenesis of MCNS. Increased IL-13 gene expression, in both CD4+ and CD8+ T-cells, correlated with elevated serum IgE levels but down-regulated IL-8 gene expression in peripheral mononuclear cells during nephrotic relapses. Upregulation of DEC-1, a growth suppressor gene, in patients in relapse was demonstrated. We postulate that upregulation of DEC-1 may be associated with regulatory nuclear factor (NF)-kB pathway.
URI: http://scholarbank.nus.edu.sg/handle/10635/14066
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Title.PDF16.24 kBAdobe PDF

OPEN

NoneView/Download
Table.PDF124.07 kBAdobe PDF

OPEN

NoneView/Download
Chapter1.PDF263.05 kBAdobe PDF

OPEN

NoneView/Download
Chapter2.PDF191.78 kBAdobe PDF

OPEN

NoneView/Download
Chapter3.PDF103.74 kBAdobe PDF

OPEN

NoneView/Download
Chapter4.PDF132.62 kBAdobe PDF

OPEN

NoneView/Download
Chapter5.PDF69.69 kBAdobe PDF

OPEN

NoneView/Download
Chapter6.PDF145.47 kBAdobe PDF

OPEN

NoneView/Download
Chapter7.PDF291.38 kBAdobe PDF

OPEN

NoneView/Download
Chapter8.PDF44.46 kBAdobe PDF

OPEN

NoneView/Download
Reference.PDF138.08 kBAdobe PDF

OPEN

NoneView/Download
Appendix.PDF150.87 kBAdobe PDF

OPEN

NoneView/Download

Page view(s)

186
checked on Jan 22, 2018

Download(s)

1,743
checked on Jan 22, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.