Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/13959
Title: The small GTPASE - ARF like protein 1 (ARL1) is a new regulator of golgi structure and function
Authors: LU LEI
Keywords: small GTPase, ARF1, Arl1, Golgi, GRIP domain Golgin, protein trafficking
Issue Date: 31-May-2004
Source: LU LEI (2004-05-31). The small GTPASE - ARF like protein 1 (ARL1) is a new regulator of golgi structure and function. ScholarBank@NUS Repository.
Abstract: Arl1 (ARF like protein1) is a poorly understood member of ARF family small GTPases. This thesis presents an original characterization of Arl1 and its effectors. Arl1 was localized to the tans Golgi under EM. Over expression of guanine nucleotide mutants of Arl1 dramatically affects the structure and function of Golgi apparatus. Arl1-GTP was found to interact with GRIP domain of Golgins (Golgin-97, Golgin-245, GCC1 and KIAA0336). The interaction was dependent on the conserved amino acids on both switch II region of Arl1 and the GRIP domain. Collectively, the research presented in this thesis reveals Arl1 is a new regulator of Golgi structure and function and one mechanism of Arl1a??s function is that it recruits and regulates its effectors a?? GRIP domain Golgins to Golgi.
URI: http://scholarbank.nus.edu.sg/handle/10635/13959
Appears in Collections:Ph.D Theses (Open)

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