Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/137142
Title: A SYMMETRIC INCHWORM NANOWALKER
Authors: CHIANG YI HERNG
Keywords: molecular machines, nanowalker, DNA, inchworm, nanomotor
Issue Date: 30-Jun-2017
Source: CHIANG YI HERNG (2017-06-30). A SYMMETRIC INCHWORM NANOWALKER. ScholarBank@NUS Repository.
Abstract: Intracellular transport by biological nanowalkers occurs in inchworm (IW) gait as well as hand-over-hand (HOH) gait. Multiple versions of artificial inchworm nanowalkers are also realized and proposed, but all rely on different ‘head’ and ‘tail’ to gain a direction. Here we demonstrate an inchworm bipedal nanowalker made of DNA that possesses two identical legs and moves directionally along a linear track under alternating ultraviolet and visible light. The inchworm gait is confirmed by operating the walker on a DNA duplex track that is designed to show a distinctive pattern for inchworm versus hand-over-hand gait. Interestingly, the same walker exhibits stride-controlled direction reversals and IW-to-HOH gait switch when the track is systematically modified for elongated spacing between periodic binding stations for the walker. The IW and HOH regimes altogether present an integrated nanowalker mechanism, which can be used to implement nanowalkers of different gaits and directions with DNA, other biomolecules or synthetic molecules on molecular tracks, optical potentials or even solid-state substrates.
URI: http://scholarbank.nus.edu.sg/handle/10635/137142
Appears in Collections:Master's Theses (Open)

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