Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/136740
Title: NEUROPROTECTIVE EFFECT OF FLUOCINOLONE ACETONIDE ON MITOCHONDRIA IN PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY
Authors: LEE JI CHAO TRISTAN
Keywords: CIPN, Trafficking, PNS, Neuroprotection, Live-cell imaging
Issue Date: 2-Jun-2017
Source: LEE JI CHAO TRISTAN (2017-06-02). NEUROPROTECTIVE EFFECT OF FLUOCINOLONE ACETONIDE ON MITOCHONDRIA IN PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY. ScholarBank@NUS Repository.
Abstract: One side effect of paclitaxel treatment, an established chemotherapy drug, is neurotoxicity, which may lead to Paclitaxel-Induced Peripheral Neuropathy (PIPN). Paraesthesia, tingling and numbness from PIPN may result in dose reduction or premature termination of the life-saving chemotherapy. Nerves with long axons are more sensitive to paclitaxel toxicity and this can be attributed to the fact that long axons are more susceptible to the dysregulation of mitochondrial dynamics. A novel mitochondrial dual-labelling method was devised, utilising the unique advantage of a compartmentalised neuron culture system. Fluocinolone Acetonide (FA), a hydrocortisone derivative, induced significant anterograde trafficking of proximal mitochondria (PM) into distal axons as a neuroprotective mechanism against PIPN. This phenomenon mitigates the damage to the distal mitochondria (DM) population and protects the axons from neurodegeneration. FA treatment recovered the paclitaxel-induced neurotoxic changes in mitochondria dynamics suggesting that its neuroprotective mechanism involved the drug-induced engagement and rescue of the mitochondria network.
URI: http://scholarbank.nus.edu.sg/handle/10635/136740
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
LeeJCT.pdf2.45 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

25
checked on Jan 14, 2018

Download(s)

12
checked on Jan 14, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.