Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/135864
Title: IMPROVEMENT OF CARDIAC FUNCTION AND ATTENUATION OF CARDIAC REMODELING AFTER MYOCARDIAL INFARCTION USING AUTOLOGOUS PLATELET RICH PLASMA AND HYALURONIC ACID-BASED HYDROGEL
Authors: VU DUC THANG
Keywords: Platelet-rich plasma, Hyaluronic-acid, Hydrogel, Porcine, Myocardial Infarction, Intramyocardial injection
Issue Date: 19-Aug-2016
Source: VU DUC THANG (2016-08-19). IMPROVEMENT OF CARDIAC FUNCTION AND ATTENUATION OF CARDIAC REMODELING AFTER MYOCARDIAL INFARCTION USING AUTOLOGOUS PLATELET RICH PLASMA AND HYALURONIC ACID-BASED HYDROGEL. ScholarBank@NUS Repository.
Abstract: Myocardial infarction is still one of the leading causes of morbidity and mortality in the world. In the present study, we aimed to develop a large scale, clinically relevant therapy for myocardial restoration, based on autologous platelet-rich plasma (PRP) and a hyaluronic acid-based hydrogel (HA), via minimally invasive intervention . Using a porcine model of acute, myocardial infarction (MI), 1-hour delay injection of activated PRP or HA to the core- and peri-infarct areas independently resulted in significant improvements of cardiac function and less adverse ventricular remodeling. The combination of activated autologous PRP in the HA had synergistic effects on ameliorating cardiac dysfunction and remodeling after acute MI. Further control of oxidative stress and excessive inflammation with antioxidant and anti-inflammatory supplements might enhance the effects of the composite of PRP and HA. The measurable and durable effects of the composite delivered via mini-thoracotomy might make it suitable for a large-scale myocardial restoration.
URI: http://scholarbank.nus.edu.sg/handle/10635/135864
Appears in Collections:Ph.D Theses (Open)

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