IMPROVEMENT OF CARDIAC FUNCTION AND ATTENUATION OF CARDIAC REMODELING AFTER MYOCARDIAL INFARCTION USING AUTOLOGOUS PLATELET RICH PLASMA AND HYALURONIC ACID-BASED HYDROGEL

Abstract

Myocardial infarction is still one of the leading causes of morbidity and mortality in the world. In the present study, we aimed to develop a large scale, clinically relevant therapy for myocardial restoration, based on autologous platelet-rich plasma (PRP) and a hyaluronic acid-based hydrogel (HA), via minimally invasive intervention . Using a porcine model of acute, myocardial infarction (MI), 1-hour delay injection of activated PRP or HA to the core- and peri-infarct areas independently resulted in significant improvements of cardiac function and less adverse ventricular remodeling. The combination of activated autologous PRP in the HA had synergistic effects on ameliorating cardiac dysfunction and remodeling after acute MI. Further control of oxidative stress and excessive inflammation with antioxidant and anti-inflammatory supplements might enhance the effects of the composite of PRP and HA. The measurable and durable effects of the composite delivered via mini-thoracotomy might make it suitable for a large-scale myocardial restoration.