Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/135851
Title: COMPUTATIONAL STUDIES ON THE STRUCTURAL ASPECTS OF PROTEIN-PEPTIDE INTERACTIONS
Authors: NGUYEN THANH BINH
Keywords: protein-peptide interaction, computational approaches, X-ray
Issue Date: 12-Jan-2017
Citation: NGUYEN THANH BINH (2017-01-12). COMPUTATIONAL STUDIES ON THE STRUCTURAL ASPECTS OF PROTEIN-PEPTIDE INTERACTIONS. ScholarBank@NUS Repository.
Abstract: Proteins mediate biological important processes by interacting with other biomolecules, namely, proteins, peptides, sugars, lipids or nucleic acids. This thesis presents my works on proteinpeptide interactions, and more specifically on protein- polyproline type II helix (PPII) peptide interaction. These interactions are crucial to several processes such as signaling pathways, localization, immune response, post-translational modifications etc. Three different aspects of protein-PPII interaction have been studied to decipher the specificity of these interactions, including refining two X-ray crystal structures of protein-PPII complex, applying molecular dynamics simulation on protein-PPII complex to understand the peptide editing mechanism, and predicting the binding sites of PPII peptide. One other aspect, pKa prediction of ionizable residues in proteins, which is important to understanding protein functions as well as protein-peptide interactions is also presented in this thesis.
URI: http://scholarbank.nus.edu.sg/handle/10635/135851
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
NguyenTB-signed.pdf8.98 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

90
checked on Dec 14, 2018

Download(s)

53
checked on Dec 14, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.