ASPIRIN IN COLORECTAL CANCER PREVENTION: A LOOK AT ITS COST-EFFECTIVENESS ANALYSES IN THE UNITED STATES, WITH EMPIRICAL INVESTIGATIONS TO SUPPORT MODEL ADAPTATIONS FOR SINGAPORE

Abstract

The growing prevalence of colorectal cancer (CRC) and its potential economic and humanistic impact make it an imperative to study ways to better prevent and control it. Aspirin has established uses in the secondary prevention of various cardiovascular conditions. Recent evidence suggest that aspirin can prevent cancer incidence, spread, and deaths, with its strongest evidence found in CRC. The main aim of this thesis is to evaluate the cost-effectiveness of aspirin in preventing CRC. It is organised into two parts – first, the development of Markov models to separately evaluate aspirin’s cost-effectiveness in primary and secondary prevention of CRC from the United States (US) perspective, and second, the generation of selected model input in an attempt to adapt the models for Singapore.