Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/134676
Title: ROLE OF CD137 SIGNALING IN IMMUNE DEVIATION OF HODGKIN LYMPHOMA AND ITS UTILISATION IN DEVELOPMENT OF IMMUNOTHERAPY
Authors: SAKTHI RAJENDRAN
Keywords: Hodgkin lymphoma, CD137, IL-13,immune deviation, EBV, LMP1
Issue Date: 17-Aug-2016
Citation: SAKTHI RAJENDRAN (2016-08-17). ROLE OF CD137 SIGNALING IN IMMUNE DEVIATION OF HODGKIN LYMPHOMA AND ITS UTILISATION IN DEVELOPMENT OF IMMUNOTHERAPY. ScholarBank@NUS Repository.
Abstract: CD137, a member of the tumor necrosis factor receptor (TNFR) superfamily has been reported to be ectopically expressed on Hodgkin and Reed-Sternberg (HRS) cells, the malignant cells in Hodgkin lymphoma (HL). Here we report that, CD137 signaling in HRS cells induces the secretion of IL-13, a Th2 cytokine. IL-13 in conditioned supernatants from CD137-stimulated HRS cell lines inhibits the secretion of an essential Th1 cytokine, IFN-in peripheral blood mononuclear cells. Hence, CD137-induced IL-13 secretion facilitates escape of HRS cells from immune surveillance, through downregulation of IFN-Γ. Targeting CD137 can be a potential therapeutic option for HL patients. Bi-specific antibodies against CD137 and CD30 were generated and tested for their ability to preferentially lyse CD30+CD137+ HRS cells in vitro. To summarize, this study has identified CD137 signaling as a mechanism of immune deviation in HL, and evaluated the efficacy of bi-specific antibodies against CD30 and CD137 as a potential immunotherapy for HL.
URI: http://scholarbank.nus.edu.sg/handle/10635/134676
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