Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/134243
Title: Studies on the specificity of a serine-esterase inhibitor, phenylmethylsulfonyl fluoride (PMSF)
Authors: Roy, A.C. 
Karim, S.M.M.
Issue Date: 1981
Source: Roy, A.C., Karim, S.M.M. (1981). Studies on the specificity of a serine-esterase inhibitor, phenylmethylsulfonyl fluoride (PMSF). IRCS Medical Science 9 (3) : 226-. ScholarBank@NUS Repository.
Abstract: Phenylmethylsulfonyl fluoride (PMSF), a known inhibitor of serine-proteinase activity, was tested for its specificity against a few other hydrolases by conventional procedures using standard substrates. The results show that the compound had no effect on serum leucine and cystine aminopeptidase and calf intestine alkaline phosphatase activity. However, it significantly inhibited phosphodiesterase (Crotalus atrox), trypsin (bovine pancreas), butyrylcholinesterase (horse serum), acid phosphatase (potato), acetylcholinesterase (bovine erythrocytes) and β-glucuronidase (E. coli) activity in a dose-related way and in decreasing order of potency. The study suggests that PMSF is not a selective inhibitor of serine esterases.
Source Title: IRCS Medical Science
URI: http://scholarbank.nus.edu.sg/handle/10635/134243
ISSN: 03056651
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

11
checked on Jan 14, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.