Please use this identifier to cite or link to this item: https://doi.org/10.1080/10715769900301611
Title: Time course of dopaminergic cell death and changes in iron, ferritin and transferrin levels in the rat substantia nigra after 6-hydroxydopamine (6-OHDA) lesioning
Authors: He, Y.
Lee, T. 
Leong, S.K. 
Keywords: 6-hydroxydopamine
Dopaminergic cell death
Ferritin
Iron
Parkinson's disease
Substantia nigra
Transferrin
Issue Date: 1999
Citation: He, Y., Lee, T., Leong, S.K. (1999). Time course of dopaminergic cell death and changes in iron, ferritin and transferrin levels in the rat substantia nigra after 6-hydroxydopamine (6-OHDA) lesioning. Free Radical Research 31 (2) : 103-112. ScholarBank@NUS Repository. https://doi.org/10.1080/10715769900301611
Abstract: Parkinson's disease is characterized by dopaminergic cell death in the substantia nigra. The underlying mechanism is, however, unknown. Though there are increasing lines of evidence showing iron accumulation in the Parkinsonian substantia nigra, it still remains obscure whether increased iron is the primary cause of dopaminergic cell death, or just a consequence of the pathological process. It is also unclear how iron gains access to the Parkinsonian SN. To gain more under standing in these areas, the present study investigated the time course of dopaminergic cell death and of changes in the level of iron, ferritin and transferrin. The results showed that iron was increased after the significant nigral dopaminergic cell death induced by 6-hydroxydopamine injection into the rat substantia nigra. On the other hand, the expression of transferrin was decreased. However, there was a temporal increase in the number of ferritin positive microglia. The results indicated that iron increase was not the primary cause of dopaminergic cell death in the Parkinsonian rat. It was most likely the result of an accumulation of iron-laden microglia.
Source Title: Free Radical Research
URI: http://scholarbank.nus.edu.sg/handle/10635/134116
ISSN: 10715762
DOI: 10.1080/10715769900301611
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