Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/134001
Title: The roles of α2-adrenoceptors in the nucleus reticularis gigantocellularis and vagal mechanism in the cardiovascular suppressive effects of guanabenz in the rat
Authors: Lim, H.C. 
Chan, S.H.H.
Keywords: α2-adrenoceptor
bradycardia
guanabenz
heart contractility reduction
nucleus reticularis gigantocellularis
rat
vagal mechanism hypotension
Issue Date: 2-Jan-1986
Source: Lim, H.C., Chan, S.H.H. (1986-01-02). The roles of α2-adrenoceptors in the nucleus reticularis gigantocellularis and vagal mechanism in the cardiovascular suppressive effects of guanabenz in the rat. Neuroscience Letters 63 (1) : 45-50. ScholarBank@NUS Repository.
Abstract: In pentobarbital-anesthetized rats, pretreatment with yohimbine (10 μg), which was microinjected into the bilateral nucleus reticularis gigantocellularis (NRGC), significantly antagonized the reduction in arterial pressure, and the force and rate of heart contraction normally promoted by systemic administration of guanabenz (10 μg/kg, i.v.). At the same time, the vasodepressive as well as negative inotropic and chronotropic effects of direct application of guanabenz (500 ng) into the NRGC were attenuated by bilateral cervical vagotomy or atropine sulfate (1 mg/kg, i.v.). We conclude that guanabenz may promote antihypertension by activating the α2-adrenoceptors in the NRGC, which in turn elicits cardiovascular suppression by at least facilitating the vagal outflows to the heart. © 1986.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/134001
ISSN: 03043940
Appears in Collections:Staff Publications

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