Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/134000
Title: Pulmonary edema as a cause for fulminant death following microinjection of kainic acid into the rat medulla oblongata
Authors: Chan, S.H.H.
Chong, A.P.Y.
Ong, B.T.
Chong, O.K.
Lim, H.C. 
Keywords: fulminant death
kainic acid
medulla oblongata rat
neurotoxicity
pulmonary edema
Issue Date: 18-Dec-1985
Citation: Chan, S.H.H., Chong, A.P.Y., Ong, B.T., Chong, O.K., Lim, H.C. (1985-12-18). Pulmonary edema as a cause for fulminant death following microinjection of kainic acid into the rat medulla oblongata. Neuroscience Letters 62 (3) : 341-346. ScholarBank@NUS Repository.
Abstract: The present study confirmed histopathologically the suggestion that pulmonary edema may underlie the fulminant death following microinjection of kainic acid into many medullary sites in rats anesthetized with pentobarbital sodium. We also observed a sustained elevation in systemic arterial pressure, cardiac contractility and heart rate before the animal succumbed to kainate neurotoxicity. It is suggested that the increased systemic hydrostatic pressure may retrogradely promote pulmonary hypertension that precipitates pulmonary edema. © 1985.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/134000
ISSN: 03043940
Appears in Collections:Staff Publications

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