Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/133955
Title: Ranitidine inhibits adrenergic transmission in the rat isolated anococcygeus muscle
Authors: Gwee, M.C.E. 
Cheah, L.S.
Keywords: 4-aminopyridine
Adrenergic transmission
Anococcygeus
Prejunctional inhibition
Ranitidine
Issue Date: 1992
Citation: Gwee, M.C.E., Cheah, L.S. (1992). Ranitidine inhibits adrenergic transmission in the rat isolated anococcygeus muscle. Clinical and Experimental Pharmacology and Physiology 19 (6) : 411-413. ScholarBank@NUS Repository.
Abstract: 1. The effects of ranitidine on adrenergic transmission in the rat isolated anococcygeus muscle were investigated. 2. Cumulative doses (2-8 mmol/L) of ranitidine produced a concentration-dependent inhibition of motor responses of the rat isolated anococcygeus muscle evoked by field stimulation (20-25 V, 10 Hz for 10 s, 1 ms pulse width) every 2 min, but also potentiated the contractile response to exogenous noradrenaline (5 μmol/L). The inhibited motor responses recovered rapidly and completely after washing out ranitidine. 3. 4-Aminopyridine (100 μmol/L) effectively reversed the partially inhibited (55% or greater) motor responses. 4. The results strongly suggest that ranitidine can inhibit adrenergic transmission in the anococcygeus muscle by a prejunctional mechanism with, presumably, consequent development of supersensitivity of the effector cells to noradrenaline.
Source Title: Clinical and Experimental Pharmacology and Physiology
URI: http://scholarbank.nus.edu.sg/handle/10635/133955
ISSN: 03051870
Appears in Collections:Staff Publications

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