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|Title:||Ranitidine inhibits adrenergic transmission in the rat isolated anococcygeus muscle|
|Authors:||Gwee, M.C.E. |
|Citation:||Gwee, M.C.E., Cheah, L.S. (1992). Ranitidine inhibits adrenergic transmission in the rat isolated anococcygeus muscle. Clinical and Experimental Pharmacology and Physiology 19 (6) : 411-413. ScholarBank@NUS Repository.|
|Abstract:||1. The effects of ranitidine on adrenergic transmission in the rat isolated anococcygeus muscle were investigated. 2. Cumulative doses (2-8 mmol/L) of ranitidine produced a concentration-dependent inhibition of motor responses of the rat isolated anococcygeus muscle evoked by field stimulation (20-25 V, 10 Hz for 10 s, 1 ms pulse width) every 2 min, but also potentiated the contractile response to exogenous noradrenaline (5 μmol/L). The inhibited motor responses recovered rapidly and completely after washing out ranitidine. 3. 4-Aminopyridine (100 μmol/L) effectively reversed the partially inhibited (55% or greater) motor responses. 4. The results strongly suggest that ranitidine can inhibit adrenergic transmission in the anococcygeus muscle by a prejunctional mechanism with, presumably, consequent development of supersensitivity of the effector cells to noradrenaline.|
|Source Title:||Clinical and Experimental Pharmacology and Physiology|
|Appears in Collections:||Staff Publications|
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